Termination of translation requires a termination signal, and a release factor
Explanation:
There are 3 stops codons of the 64 possible codons. These are UAA, UAG, or UGA. These do not code for amino acids and are therefore not recognized by any anticodons for any of the ‘charged’ tRNA. These codons, are recognized by release factors that ‘knock off’ the newly synthesized peptide from the ribosome through peptidyl-tRNA hydrolysis. There are several release factors (RF1 and RF2) in bacteria but in eukaryotes only one RF has been discovered to recognize the 3 stop codons.
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